Research Champion

Rafael Freire
Associate Professor
Email: rafael.freire@queensu.ca
This research stream focuses on neurobiology, biomarkers, neurostimulation, and psychopharmacology in anxiety disorders and obsessive-compulsive disorders.
Key researchers in this stream
Elisa Brietzke
Professor, Department of Psychiatry, Queen’s University
elisa.brietzke@queensu.ca
Claudio Soares
Professor, Department of Psychiatry, Queen’s University
c.soares@queensu.ca
Current research projects
Trigeminal nerve stimulation in treatment-resistant generalized anxiety disorder: a feasibility study
PI: Rafael Freire
Co-investigators: Elisa Brietzke and Claudio Soares
Adjunctive Treatment with L-methylfolate for Treatment-Resistant Generalized Anxiety Disorder: a Pilot Study
PI: Rafael Freire
Co-investigators: Elisa Brietzke and Claudio Soares
Cross-Cultural Patterns of Consultation-Liaison Psychiatry Referrals: a Comparison between a Canadian and an Omani Hospital
PI: Rafael Freire
Co-investigators: Elisa Brietzke, Elvina Chu and Claudio Soares
Anxiolytic effects of serotoninergic psychedelics on patients with psychiatric disorders: a systematic review and meta-analysis
PI: Rafael Freire
Co-investigators: Elisa Brietzke
A Phase 2a, Placebo-Controlled Randomized, Double-Blind Trial to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults with Generalized Anxiety Disorder
PI: Claudio Soares
Co-investigators: Rafael Freire
Publication list (last 5 years):
1. Kyriakoulis P, Freire, RCD. Fear Circuits in Panic Disorder: An Update. Alpha Psychiatry 2025; 26(3): 44174. doi: 10.31083/AP44174.
2. Cuyler R, Mojgani JS, Albuquerque da Costa JC, Freire RC. Capnometry-Guided Respiratory Intervention in Veteran PTSD: Impact on Symptom Clusters. Healthcare 2025;13(4):390. doi: 10.3390/healthcare13040390.
3. Kyriakoulis P, Wijaya C, Quagliato L, Freire RC, Nardi AE. Neurocircuitry and Neuroanatomy in Panic Disorder: A Systematic Review. Alpha Psychiatry 2025; 26(1): 38756. https://doi.org/10.31083/AP38756.
4. Marcos Fidry, Morena Mourao Zugliani, Mariana Costa do Cabo, Renan Machado Martins, Manuella Assad Gomez, Clara Gitahy Falcão Faria, Antonio Egidio Nardi, Rafael C Freire. Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis. Clin Pract Epidemiol Ment Health 2024, Dec 3:20:e17450179337258. doi: 10.2174/0117450179337258241031035148. PMID: 39839219 PMCID: PMC11748058.
5. Cabo MC, Costa JCA, Nardi AE, Freire RC. Childhood Separation Anxiety Disorder and Panic Disorder: Differences Between Respiratory and Nonrespiratory Subtypes. Prim Care Companion CNS Disord 2024, 26(5):24m03709. doi: 10.4088/PCC.24m03709. PMID: 39320848.
6. Moraes ACN, Wijaya C, Freire R, Quagliato LA, Nardi AE, Kyriakoulis P. Neurochemical and genetic factors in panic disorder: a systematic review. Transl Psychiatry 2024, 14(1):294. doi: 10.1038/s41398-024-02966-0. PMID: 39025836 PMCID: PMC11258274.
7. Garakani A, Buono FD, Salehi M, Funaro MC, Klimowicz A, Sharma H, Faria CGF, Larkin K, Freire RC. Antipsychotic agents in anxiety disorders: An umbrella review. Acta Psychiatr Scand 2024, 149(4):295-312. doi: 10.1111/acps.13669. PMID: 38382649.
8. Al-Mahrouqi T, Al Alawi M, Freire RC. (2023) Dexmedetomidine in the Treatment of Depression: An Up-to-date Narrative Review. Clin Pract Epidemiol Ment Health.; 19:e174501792307240. doi: 10.2174/17450179-v19-230823-2023-4.
9. Freire RCR, Nardi AE. (2023) Is it possible to prevent relapse in panic disorder? Expert Rev Neurother.; 23(8):677-679. doi: 10.1080/14737175.2023.2229955. Epub 2023 Jun 26.
10. Brietzke E, Gomes FA, Gerchman F, Freire RCR. (2023) Should systematic reviews and meta-analysis include data from preprints? Trends Psychiatry Psychother.;45:1-2. doi: 10.47626/2237-6089-2021-0324. Epub 2021 Sep 8.
11. Faria CGF, de Matos UMA, Llado-Medina L, Pereira-Sanchez V, Freire R, Nardi AE. (2022) Understanding and addressing COVID-19 vaccine hesitancy in low and middle income countries and in people with severe mental illness: Overview and recommendations for Latin America and the Caribbean. Front Psychiatry.;13:910410. doi: 10.3389/fpsyt.2022.910410.
12. Garakani A, Freire RC, Buono FD, Thom RP, Larkin K, Funaro MC, Salehi M, Perez-Rodriguez MM. (2022) An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol. PLoS One, Vol. 17(6):e0269772
13. Ferreira-Garcia R, Costa MA, Gonçalves FG, de Nonohay RG, Nardi AE, Freire RCDR, Manfro GG. (2021) Heart rate variability: A biomarker of selective response to mindfulness-based treatment versus fluoxetine in generalized anxiety disorder. J Affect Disord.;295:1087-1092. doi: 10.1016/j.jad.2021.08.121. Epub 2021 Sep 2.
14. Kyriakoulis P, Kyrios M, Nardi AE, Freire RC, Schier M. (2021) The Implications of the Diving Response in Reducing Panic Symptoms. Front Psychiatry.;12:784884. doi: 10.3389/fpsyt.2021.784884.
15. Garakani, A.; Freire, R. C.; Murrough, J. W. (2021). Pharmacotherapy of Anxiety Disorders: Promises and Pitfalls. Front Psychiatry, 12: 662963.
16. Freire, R. C. and V. A. Santos (2021). Features shared between fear of missing out on rewarding experiences (FOMO) and internet gaming disorder. Braz J Psychiatry, 43 (2): 129-130.
17. Zugliani, M.M., Fidry, M., Steffen, R., Lan, C., Brietzke, E., Milev, R., Nardi, A.E. and Freire, R.C. (2021). Clinical effectiveness of non-TMS neurostimulation in depression: Clinical trials from 2010 to 2020. Progress in Neuro-Psychopharmacology and Biological Psychiatry:110:110287. doi: 10.1016/j.pnpbp.2021.110287. Epub 2021 Feb 19.
Research grants (internal and external)
Name of awarding organisation: Faculty of Health Sciences, Queen’s University
Amount in $CAN: 30,000
Duration of funding: 2 years
Name of awarding organisation: Biohaven Pharmaceuticals Inc.
Amount in $CAN: up to 243,000 (deliverable-based invoicing)
Duration of funding: open-ended
Name of awarding organisation: Department of Psychiatry, Queen’s University
Amount in $CAN: 10,000
Duration of funding: 1 year
Name of awarding organisation: Department of Psychiatry, Queen’s University
Amount in $CAN: 10,000
Duration of funding: 1 year
Current students
-
Morená Zugliani - Postdoctoral Research
Mariana Cabo - PhD candidate
Juliette Mojgani - Medical Student
Eknoor Thind - Undergraduate Student
Patia Karmiris - Undergraduate Student
Other information
Link to Queen's University Anxiety Research Lab (QAnxiety) - https://qanxiety.ca/
ResearchGate profile: https://www.researchgate.net/profile/Rafael_Freire
Web of Science profile: https://www.webofscience.com/wos/author/record/872338
Scopus: https://www.scopus.com/authid/detail.uri?authorId=34067584800
ORCID: https://orcid.org/0000-0003-3875-4601
Google Scholar: Rafael C R Freire - Google Scholar