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Current Clinical Studies and Research Projects

Alavi N, Prost E, Reshetukha T - Do Clinicians use the common suicidal attempt predictors, in managing patients with suicidal ideation? (12-2013/12-2018) American Foundation for Suicide Prevention 

Al-Blowi M, Wijeratne N, Nadkarni P, Hussain M, Wijeratne T – Effect of Selective Serotonin reuptake Inhibitors On Bone Health: A systemic review and meta-analysis (4-2016/4-2017) Faculty of Health Sciences Queen’s University – Women’s Giving Circle Grant 

Anagnostou E, Liu X, Ayub M, Fitzpatrick R, Hiscock-Jones C, Jones J, Kelley B, Sandup A, Smith G – Province of Ontario Neurodevelopmental Disorders Network (9-2015/9-2018) Ontario Brain Institute 

Ayub M, McQueen M, Jones J, Naeem F – Feasibility study of cognitive behavior therapy (CBT) based guided self-help intervention manual for Depression and Anxiety in individuals with intellectual disabilities (ID) (4-2016/4-2018) Queen’s Department of Psychiatry 

Bajaj N, Finch S, Groll D, Darling M, Tran T – Study of Outcomes of the Short Intensive Mental Health Day Treatment Program (6-2015/N/A) Queen’s University 

Black S, Freedman M, Seitz D – Ontario Neurodegenerative Disease Research Initiative (1-2016 / N/A) Ontario Brain Institute 

Bowie C, Jokic R – Remote Cognitive Remediation for Acute Depression (1-2015/N/A) CIHR Grant 

Cabrera-Abreu C – The Role of Vitamin D in Patients with Treatment Refractory Depression (9-2015/N/A) Research Initiated Grant

Cramm H, Khalid-Khan S, Xie Y, Marchand P, Reddy P, Groll D – Targeting the Mental Health of Canadian Children Growing up in Military Families (12-2014/12-2018) Health Research Foundation Interdisciplinary Health Research Team Grant

Duffy A, Wong A, Grof P – Identifying Rare Variants for Bipolar Disorder (7-2015/ 12-2016) Alberta Innovates Health Solutions 

Duffy A, Geddes J, Saunders K, Grof P, Horrocks J – Refined Prospective Clinical Phenotyping Using True Colours Remote Capture Methods in Youth at Familial Risk of Mood Disorders ( 5-2015 / 5-2017) Hotchkiss Brain Institute 

Duffy A, Horrocks J, Grof P, Wong A – The Early Course of Bipolar Disorder: From Genetic Risk to Illness Onset (3-2011 / 4-2017) Canadian Institutes of Health Research 

Fitzpatrick R, Lip A, Liu X, Groll D – CFMS Wellness Challenge. Evaluating a new initiative to promote the development of resilience in medical students (6-2016/6-2018) Queen’s Department of Psychiatry 

Fitzpatrick R, Jokic R, Prost E, Jones C – Teaching assessment and dictations skills to psychiatry residents using standardized patients (6-2015/9-2016) Queen’s Department of Psychiatry 

Holmes L, Hancock P, Jones J, Martin L, Morris S, Pathak M – Provincial Awareness of Developmental Disabilities in the Criminal Justice System: DS Expert Panel Project (2-2015/2-2017) Inter-ministerial Mental Health and Justice Committee (MCSS/MOHLTC/MCSCS)

Hollenstein T, Khalid-Khan S, Granic I – Mindlight: A videogame Intervention to Reduce Child Anxiety (8-2014/8-2016) OMHF 

Husain N, Naeem F – Multicenter Randomized Control Trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin – ROSHNI (1-2016 / 1-2020) NIHR HTA 

Husain N, Naeem F – Multicenter RCT to evaluate the clinical and cost-effectiveness of a cultural Adapted therapy (C-MAP) in patients with a history of self-harm (6-2015/12-2018) Medical Research Council (MRC)/Wellcome Trust/DFID 

Hussain M, Seitz D, Herrmann N, Ismail Z, Quinn T – Improving Quality of Care for Older Adults with Post-Stroke Depression: Development of Screening Algorithms (10-2016/10-2018) Queen’s Department of Psychiatry Internal Grant 

Iftene F – Mental Disorders in Adults with Childhood Out-of-Home Placements (1-2015 / 12-2017) Queen’s Department of Psychiatry 

Jokic R – Effect of Positive Airway Pressure Treatment on Mood, Anxiety and Cognitive Function in Treatment Resistant Depressed Subjects with Obstructive Sleep Apnea (1-2009/ N/A) RESMED Foundation 

Jokic R, du Toit R, Fitzpatrick M, Milev R, Lowe A, David M – Treatment Resistant Depression and Obstructive Sleep Apnea: Effect of Treatment with Continuous Positive Airway Pressure (CPAP) on Mood, Anxiety and Quality of Life (10-2006/12-2018) Queen’s University Research Initiation Grant 

Jokic R, Cabrera-Abreu C, Kolar D – Treatment resistant depression and obstructive sleep apnea: Effect of treatment with continuous positive airway pressure (CPAP) on mood, anxiety and quality of life (7-2009/N/A) External Funding 

Jokic R, Milev R, Kolar D, Cabrera C – CNS-011-12 Bipolar disorder and sleep apnea-investigating the co-morbidity and impact on neurocognition and quality of life (1-2014/12-2019) Queen’s RIG 

Jones J, McQueen M, Blinkhorn A, Mills MJ, Hewett L, Hall L, Li J, Ayub M – Adapted Dialectical Behaviour Therapy (DBT) group for Individuals with Intellectual Disabilities and Emotional Dysregulation Difficulties (9-2015/9-2017) Queen’s Department of Psychiatry 

Kennedy S, Jokic R – CANBIND/OBI Integrated Biological Markers for the Prediction of Treatment Response in Depression (1-2013 / N/A) CANBIND 

Kennedy S, Soares C – CAN-BIND Canadian Biomarker Integration Network in Depression (5-2012/5-2017) Ontario Brain Institute 

Kirkham J, Seitz D – Canadian Frailty Network Interdisciplinary Fellowship Award (1-2016/12-2016) Canadian Frailty Network 

Khalid-Khan S, Reddy S – A Multicentre, Double blind, Placebo and Active Controlled Parallel Group Evaluation of the Safety and Efficacy of Vilazodone in Pediatric Patients with Major Depressive Disorder (11-2016/12-2018) Allergan 

Khalid-Khan S, Reddy S –An Adaptive Phase II-B/III, Double-Blind, Randomized Placebo Controlled, Multi-Centre Study Of The Safety And Efficacy Of Naben ® (Sodium Benzoate), A D-Amino Acid Oxidase Inhibitor, as an Add-on Treatment Of Schizophrenia in Adolescents (10-2014/12-2018) SyneuRx International (Taiwan) Corporation 

Khalid-Khan S, Wilson C, McCart A, Jaffer A – Centralized triage for children and adolescents with mood and anxiety disorders (9-2015/9-2016) SELHIN 

Khalid-Khan S, McCart A, Wilson C – Decreasing Wait Times for Child and Youth Mental Health: Developing a Centralized Triage Process between Primary Care, Youth Mental Health Agency and Child and Adolescent Psychiatry in the Hospital: A Quality Improvement Initiative (4-2014/3-2017) SELHIN

Khalid-Khan S, Calancie O, Nesdole R – Expansion of the Centralized Triage for Children and Adolescent Neurodevelopmental Disorders (11-2015/N/A) RBC for Children’s Mental Health 

Khalid-Khan S, Khachatryan D – Prazosin Treatment of Nightmares and Sleep Disturbances Associated with PTSD in Children and Adolescents (9-2016/12-2018) Department of Psychiatry Grant

Khalid-Khan S, Booij L, Davidson J, McCart A – Preventing Aggressive Behaviour in Boys Exposed to Family Violence (11-2016/12-2019) Department of Psychiatry Internal Grant 

Khalid-Khan S, Reddy S, Roberts N – Sandbox/TELUS: Providing Patients Access to Personalized Health Care Through Accessible Youth and Provider Friendly Technology: Sandbox Project Phase 2 (10-2014/10-2017) Sandbox 

Khalid-Khan S, Reddy PS – Developing triage services in Kingston (4-2015/12-2018) SEAMO 

Kolar D, Milev R, Cabrera-Abreau C, Jokic R – The Validation of the Nepean Dysphoria Scale (6-2013/N/A) Research Initiated Grant 

Kolar D, Milev R, Cabrera C, Jokic R – A study of alertness in patients with treatment resistant depression (1-2015/12-2019) Queen’s RIG 

Liu X, Reddy P, Khalid-Khan S, Fitzpatrick R, Jones J – QPOND Genetic Studies of Autism, Neurodevelopmental and Neuropsychiatric Disorders (10-2015/10/2018) Ontario Brain Institute 

Liu X, Khalid-Khan S, Booij L – Genetics of Neuropsychiatric Disorders, including schizophrenia, mood disorders and eating disorders (11-2013/N/A) Special Grant 

Luctkar-Flude M, Groll D, Beckett L, Giroux J, Tyerman J – Exploring the effect of neurofeedback on post cancer cognitive impairment and fatigue: A pilot feasibility study (1-2016/1-2018) Canadian CAM Research Fund and Queen’s University School of Nursing 

Magaud E, Duffy A, Bentall R, Scott J – Clinical Risk Markers in the Early Stages of Bipolar Disorder (5-2015 / 5-2017) Alberta Innovates Health Solutions 

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – CANBIND-1 An Investigation of Biological Markers of Treatment Response in Depression (1-2013 / 12-2018) CANBIND and OBI 

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – Esketamine 3008 – Extension- An open label, long-term, extension safety study of intranasal Esketamine in treatment resistant depression (1-2016/12-2020) Janssen 

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – Esketamine 3001 – A randomized, double-blind, multi-centre, active-controlled study to evaluate the efficacy, safety and tolerability of fixed doses of intranasal Esketamine plus an oral antidepressant in adult subjects with treatment resistant depression (1-2016/12-2019) Janssen 

Milev R, Cabrera-Abreu C - A Randomized, Double-blind, Multicentre, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Subjects with Treatment-resistant Depression (9-2015/N/A) Janssen 

Milev R, Cabrera-Abreu C, Kolar D – An Investigation of Biological Markers of Treatment Response in Depression (4-2013 / N/A) UHN/OBI 

Milev R, Cabrera-Abreu C, Kolar D, Jokic R – Esketamine 3003-Extension – A randomized, double-blind, multicenter, active-controlled study of intranasal Esketamine plus an oral antidepressant for relapse prevention in treatment-resistant depression (1-2016 / 12-2018) Janssen 

Milev R, Cabrera-Abreu C, Kolar D – Extension – A Randomized, Double-blind, Multicenter, Active-controlled Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Treatment-Resistant Depression (12-2016 / N/A) Janssen 

Milev R, Cabrera-Abreu C, Kolar D – Extension – An Open-label long-term extension Safety Study of Intranasal Esketamine in Treatment-Resistant Depression (12-2016 / N/A) Janssen 

Milev R, Cabrera-Abreu C, Kolar D – Long-Term Follow Up Study Protocol – An Investigation of Biological Markers of Treatment Response in Depression (6-2016/N/A) UHN/OBI 

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – Mood Stabilizer Plus Antidepressant versus Mood Stabilizer Plus Placebo in the Maintenance Treatment of Bipolar Disorder (6-2013/12-2018) UBC

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – Sleep architecture in depressed patients treated with Desvenlafaxine (1-2013/12-2017) Pfizer 

Milev R, Cabrera-Abreu C – Transcranial Magnetic Stimulation (rTMS) and Deep Brain Stimulation (DBS) across Ontario sites (existing and new) using the same standardized assessment platforms (2-2014 / N/A) External Agency 

Milev R, Cabrera-Abreu C, Kolar D – Wellness Monitoring – A Collaborative Investigation of Predictors of Relapse in Major Depressive Disorder – Extension – An Investigation of Biological Markers of Treatment Response in Depression (6-2016/N/A) UHN/OBI 

Milev R, Harkness K – Stress Sensitivity and Reward Responsivity in Major Depression: A 6-month Follow Up (6-2016/5-2017) FHS, Queen’s University and Kingston General Hospital Foundation Funds 

Milev R, Iftene F – A Multicentre, 26-Week Extension Study to Evaluate the Safety and Clinical Effects of Prolonged Exposure to 1 and 2mg doses of EVP-6124, an Alpha-7 Nicotinic Acetylcholine Receptor Agonist, as an Adjunctive (1-2013 – N/A) EnVivo Pharmaceuticals Inc. 

Milev R, Iftene F – A Phase II Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial to Examine the Efficacy and Safety of 4 Oral Doses of BI 425809 Once Daily over 12-week Treatment Period in Patients with Schizophrenia (1-2016 – N/A) Boehringer-Ingelheim 

Milev R, Iftene F – Canadian Non-Interventional Prospective Cohort Study on the Real Life (1-2013 / N/A) Abilify Maintenna 

Milev R, Iftene F – ENVIVO Study: A Randomized, Double-Blind, Placebo-Controlled, Parallel, 26-Week, Phase 3 Study of 2 Doses of Alpha-7 Nicotinic Acetylcholine Receptor Agonist (EPV-6124) or Placebo as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy (1-2013 – N/A) EnVivo Pharmaceuticals Inc. 

Milev R, Iftene F, Millson R – Interventional, Randomized, Double-Blind, Active-Controlled, Fixed-Dose Study of LuAF35700 in Patients with Treatment-Resistant Schizophrenia (phase3) (1-2016 / N/A) Lundbeck 

Milev R, Iftene F – PANSS Development of a PANSS Subscale for the Clinical Staging of Schizophrenia:  Descriptive, Non-Interventional, Multi-Centre Study (1-2016/12-2017) Lundbeck 

Milev R, Iftene F – QUALIFY: A 28-week, Randomized, Open-Label Study Evaluating the Effectiveness of Aripiprazole Once-monthly Versus Paliperidone Palmitate in Adult Patients with Schizophrenia. Study Phase IIIb (1-2013 / N/A) Lundbeck 

Milev R, Jokic R – A Prospective, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Safety and Efficacy Study of Oral ELND005 as an Adjunctive Maintenance Treatment in Patients with Bipolar I Disorder (1-2013/12-2016) Elan Pharma International Inc. 

Milev R, Wallace C – The Efficacy, Safety and Tolerability of Probiotics on the Mood and Cognition of Depressed Patients (1-2016/12-2019) Lallemand and CANBIND 

Milev R, Munshi T, Marin A, Cabrera C, Jokic R, Kolar D, Liu Y – CANBIND, Biomarkers in Depression (12-2012/N/A) Lundbeck 

Milev R, Munshi T, Abdelmotaal E, Iftene F – Add on therapy for Cognitive Deficits in Schizophrenia (12-2012/N/A) Shire 

Millson R, Iftene F – Serum Vitamin C and D Levels in Clients with Schizophrenia: A Retrospective Analysis (1-2015 – N/A) Department of Psychiatry Internal Grant 

Morgan D, Kosteniuk J, Connell ME, Kirk A, Stewart N, Acan Osman B, Auer S, Bourassa C, Bracken J, Dal Bello-Haas V, Defontaines B, Farmer J, Holroyd-Leduc J, Innes A, Jacklin K, Malloy-Weir L, Miller W, Mou H, Osgood N, Osman M, Parrott E, Quail J, Rohatinsky N, Seitz D, Walker J – Design and evaluation of integrated primary health care practices for dementia in rural and remote settings (9-2016/8-2021) CIHR 

Munshi T, Parmar V, Dhaliwal S – Nicotine Dependence in mental health patients, is it being identified! (7-2013/N/A) Queen’s Department of Psychiatry 

Nadkarni P, Wang P, Reddy PS, Groll D – Awareness of driving guidelines: a transatlantic comparison (4-2016) Queen’s Department of Psychiatry Research Assistance Funds 

Nadkarni P, Bajaj N, Hassan T, Groll D, Nadkarni S – Determinants of aggression control measures: data from an acute psychiatry ward (3-2016) Queen’s Department of Psychiatry Research 

Naeem F – A pilot RCT to test the effectiveness of CBTp based guided self-help for schizophrenia (6-2015 / 11-2016) Department of Psychiatry

Naeem F, Munshi T, Khalid-Khan S – Cognitive Behaviour Therapy (CBT) based guided self-help for patients with psychosis (6-2015/N/A) Queen’s Department of Psychiatry 

Naeem F, Munshi T, Ayub M, Bowie C, Hirji A, McKenna C, Johal R, Groll D – Cognitive Behaviour Therapy (CBT) based Guided Self-Help in combination with Cognitive Remediation for patients with Psychosis (8-2015/N/A) Queen’s Department of Psychiatry 

Naeem F, Munshi T, Johal R, Hirji A, McKenna C – RCT of Resolve (Relaxation exercise, solving problems and cognitive errors): A waiting room intervention for crisis clients (7-2015/N/A) Queen’s Department of Psychiatry 

Prost E, Shamblaw A – Review of Patients Seeking Psychiatric Services at a Women’s Reproductive Clinic (1-2015 – 1-2017) Queen’s Department of Psychiatry 

Prost E, Shamblaw A – Women’s Reproductive Clinic – Relationship and Treatment Outcome (5-2016 – 6-2017) Queen’s Department of Psychiatry 

Reddy PS, Nesdole R – Prejudiced attitudes towards Aboriginals in healthcare: the psychometric properties of the old-fashioned and modern prejudiced attitudes towards Aboriginals scale (12-2015/12-2016) Queen’s Internal Grant 

Reddy PS, Khalid-Khan S – Second Generation Antipsychotic Use And Side Effect Profile In Children And Adolescents: A Five Year Retrospective Study (10-2015/10-2018) Queen’s Initiation Grant 

Reddy PS, Edgington A, Binbing – Tool development for assessing the risks associated with psych pharmaceutical agent use in children: a pilot study with Atomoxetine (10-2015/10-2018) Queen’s Grant 

Rochon PA, Bronskill SE, Austin PC, Bell CM, Farrell B, Gill SS, Gruneir A, Herrmann N, Jeffs LP, McCarthy L, Metge C, Seitz DP, Upshur R – Multi-Method Approach to Exploring Prescribing Cascades (9-2016/8-2017) 

Seitz D, Gill SS, Herrmann N, Lanctot K, Kirkham J, Le Clair K, Maxwell C, Quinn t, Rapoport R, Rochon PA, Takwoingi Y – A Systematic Review and Meta-Analysis of the Accuracy of Depression Rating Scales to Diagnose Depression in Older Adults with Alzheimer’s Disease and Other Dementias (3-2015 / 2-2016) CIHR 

Seitz D, Herrmann N, Lanctot K – Non-Stigmatizing Language in Dementia (10-2016 / 11-2017) CIHR 

Seitz D, Herrmann N, Lanctot K – Prevention and Treatment of Neuropsychiatric Symptoms of Dementia (4-2014 / 3-2019) CIHR 

Seitz D, Rochon P, Herrmann N, Lanctot K, Tierney M – Sex and Gender Differences in the Initiation and Discontinuation of Psychotropic Medications among Long-Term Care Residents with Dementia (12-2016 / 11-2018) CIHR 

Seitz D, Austin P, Hussain M, Gill SS, Eckenhoff R, Berger M, Reimer CR – Surgery, Anesthesia, and Risk of Developing Dementia (1-2015 / 12-2017) SEAMO AFP Innovation Fund 

Seitz D – Comparative Safety of Antipsychotic Medications in Older Adults with Psychotic Disorders (10-2016) CIHR 

Seitz D – Mental Health Disorders in Long-Term Care (3-2016) Physician Services Incorporated 

Seitz D – Prevalence and Correlates of Multiple Medications with QTc Effects (1-2016) Alzheimer Society of Canada Research Program 

Soares C – Assessing the Acceptability of a Mobile Application in Depression: A M-Health User-friendliness, Feasibility Pilot Study (12-2016 / 12-2017) Ontario Brain Institute 

Soares C, Kennedy S – CAN-BIND CARES: Prevention and Self-Management of Depression in the Digital Age (9-2016/9-2019) Ontario Research Fund (ORF) Research Excellence 

Soares C, Frey B, Steiner M, Minuzzi L – Midlife Women with Depression: the effects of rapid tryptophan or phenylalanine/tyrosine depletion on mood and thermoregulation in depressed subjects responsive to estrogen therapy (3-2012/3-2017) CIHR

Velkers C, Seitz D – Canadian Frailty Network Interdisciplinary Fellowship Award (1-2016/12-2016) Canadian Frailty Network 

Vincent J, Kennedy J, Ayub M – Identification of Proteomic Biomarkers for Bipolar Disorder (3-2016.N/A) University of Toronto Neuroscience Catalyst Fund 

Wang L, Kolar D – Can the Use of a Safety Checklist Lead to Improve Quality of Care in Electroconvulsive Therapy? (1-2016/N/A) Queen’s University

Warner J, O’Neil J, Luctkar-Flude M, Groll D – Hotel Dieu Hospital Kingston RNAO Best Practice Spotlight Organization Implementation Project (9-2012/9-2016) RNAO

Wijeratne T, Nadkarni P, Wijeratne N, Hussein M, Al-Blowi M – SSRI and Bone Health (7-2015 / 12‑2016) Kingston General Hospital