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Current Clinical Studies and Research Projects

The department has a wide range of research and clinical studies resources. Our research units have well-developed infrastructure to support our studies and well-trained staff that have many years of both clinical and research expertise. We strive to further the promotion and development of research activities and research excellence within the department. 

We provide opportunities for research training and support to enable the development of research interests among faculty and residents. 

Queen’s University’s Online Psychotherapy Lab (QUOPL)

Queen’s University’s Online Psychotherapy Lab (QUOPL), Led by Dr. Nazanin Alavi psychiatrist and assistant professor at department of psychiatry at Queen’s university is located at KHSC, Hotel Dieu Hospital site, Adult Mental Health Program.

QUOPL aims to improve the lives of all those affected by mental health disorders through the advancement in mental health research. QUOPL designs different online psychotherapy modules for various mental illnesses.

Our lab designs and conducts a variety of research projects through an online platform (OPTT) on the assessment, treatment, and effectiveness of different psychotherapy modalities including Cognitive Behavioural Therapy (CBT), Dialectical Behavioural Therapy (DBT), Relapse Prevention, and in the treatment of Depression and Anxiety disorders, Borderline Personality disorder, Substance use disorder and Insomnia to address the barriers in receiving psychotherapy.

Check out the QUOPL website for more information here



  1. Delivering online cognitive behavioural therapy (e-CBT) to address mental health challenges and PTSD in correctional workers
  2. Online delivery of psychotherapy, tailored to patients' suffering from mental health problems in the context of COVID-19
  3. Feasibility and Effectiveness of Delivering Cognitive Behavioural Therapy through Online Psychotherapy Tool (OPTT)  for Depression.
  4. Determining the efficacy of online cognitive behavioural therapy for Generalized Anxiety Disorder compared to pharmaceutical interventions
  5. Delivering Electronic Cognitive Behavioural Therapy to Patients with Bipolar Disorder and Residual Depressive Symptoms
  6. Investigating the Effects of Electronically Delivered Cognitive Behavioural Therapy on Brain Structure in Individuals with Obsessive-Compulsive Disorder using Functional MRI
  7. Developing and Implementing an Online Psychotherapy Program to Address Mental Health Challenges in Oncology and Palliative Care
  8. Internet-based mental state monitoring using patient's textual data




Lead: Dr. Nazanin Alavi, MD, FRCPC 

Psychiatrist: Dr. Megan Yang, MD, FRCPC 

More information can be found on the QUOPL website here


Department of Psychaitry Research Projects 

Alavi N, Prost E, Reshetukha T - Do Clinicians use the common suicidal attempt predictors, in managing patients with suicidal ideation? (12-2013/12-2018) American Foundation for Suicide Prevention 

Al-Blowi M, Wijeratne N, Nadkarni P, Hussain M, Wijeratne T – Effect of Selective Serotonin reuptake Inhibitors On Bone Health: A systemic review and meta-analysis (4-2016/4-2017) Faculty of Health Sciences Queen’s University – Women’s Giving Circle Grant 

Anagnostou E, Liu X, Ayub M, Fitzpatrick R, Hiscock-Jones C, Jones J, Kelley B, Sandup A, Smith G – Province of Ontario Neurodevelopmental Disorders Network (9-2015/9-2018) Ontario Brain Institute 

Ayub M, McQueen M, Jones J, Naeem F – Feasibility study of cognitive behavior therapy (CBT) based guided self-help intervention manual for Depression and Anxiety in individuals with intellectual disabilities (ID) (4-2016/4-2018) Queen’s Department of Psychiatry 

Bajaj N, Finch S, Groll D, Darling M, Tran T – Study of Outcomes of the Short Intensive Mental Health Day Treatment Program (6-2015/N/A) Queen’s University 

Black S, Freedman M, Seitz D – Ontario Neurodegenerative Disease Research Initiative (1-2016 / N/A) Ontario Brain Institute 

Bowie C, Jokic R – Remote Cognitive Remediation for Acute Depression (1-2015/N/A) CIHR Grant 

Cabrera-Abreu C – The Role of Vitamin D in Patients with Treatment Refractory Depression (9-2015/N/A) Research Initiated Grant

Cramm H, Khalid-Khan S, Xie Y, Marchand P, Reddy P, Groll D – Targeting the Mental Health of Canadian Children Growing up in Military Families (12-2014/12-2018) Health Research Foundation Interdisciplinary Health Research Team Grant

Duffy A, Wong A, Grof P – Identifying Rare Variants for Bipolar Disorder (7-2015/ 12-2016) Alberta Innovates Health Solutions 

Duffy A, Geddes J, Saunders K, Grof P, Horrocks J – Refined Prospective Clinical Phenotyping Using True Colours Remote Capture Methods in Youth at Familial Risk of Mood Disorders ( 5-2015 / 5-2017) Hotchkiss Brain Institute 

Duffy A, Horrocks J, Grof P, Wong A – The Early Course of Bipolar Disorder: From Genetic Risk to Illness Onset (3-2011 / 4-2017) Canadian Institutes of Health Research 

Fitzpatrick R, Lip A, Liu X, Groll D – CFMS Wellness Challenge. Evaluating a new initiative to promote the development of resilience in medical students (6-2016/6-2018) Queen’s Department of Psychiatry 

Fitzpatrick R, Jokic R, Prost E, Jones C – Teaching assessment and dictations skills to psychiatry residents using standardized patients (6-2015/9-2016) Queen’s Department of Psychiatry 

Holmes L, Hancock P, Jones J, Martin L, Morris S, Pathak M – Provincial Awareness of Developmental Disabilities in the Criminal Justice System: DS Expert Panel Project (2-2015/2-2017) Inter-ministerial Mental Health and Justice Committee (MCSS/MOHLTC/MCSCS)

Hollenstein T, Khalid-Khan S, Granic I – Mindlight: A videogame Intervention to Reduce Child Anxiety (8-2014/8-2016) OMHF 

Husain N, Naeem F – Multicenter Randomized Control Trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin – ROSHNI (1-2016 / 1-2020) NIHR HTA 

Husain N, Naeem F – Multicenter RCT to evaluate the clinical and cost-effectiveness of a cultural Adapted therapy (C-MAP) in patients with a history of self-harm (6-2015/12-2018) Medical Research Council (MRC)/Wellcome Trust/DFID 

Hussain M, Seitz D, Herrmann N, Ismail Z, Quinn T – Improving Quality of Care for Older Adults with Post-Stroke Depression: Development of Screening Algorithms (10-2016/10-2018) Queen’s Department of Psychiatry Internal Grant 

Iftene F – Mental Disorders in Adults with Childhood Out-of-Home Placements (1-2015 / 12-2017) Queen’s Department of Psychiatry 

Jokic R – Effect of Positive Airway Pressure Treatment on Mood, Anxiety and Cognitive Function in Treatment Resistant Depressed Subjects with Obstructive Sleep Apnea (1-2009/ N/A) RESMED Foundation 

Jokic R, du Toit R, Fitzpatrick M, Milev R, Lowe A, David M – Treatment Resistant Depression and Obstructive Sleep Apnea: Effect of Treatment with Continuous Positive Airway Pressure (CPAP) on Mood, Anxiety and Quality of Life (10-2006/12-2018) Queen’s University Research Initiation Grant 

Jokic R, Cabrera-Abreu C, Kolar D – Treatment resistant depression and obstructive sleep apnea: Effect of treatment with continuous positive airway pressure (CPAP) on mood, anxiety and quality of life (7-2009/N/A) External Funding 

Jokic R, Milev R, Kolar D, Cabrera C – CNS-011-12 Bipolar disorder and sleep apnea-investigating the co-morbidity and impact on neurocognition and quality of life (1-2014/12-2019) Queen’s RIG 

Jones J, McQueen M, Blinkhorn A, Mills MJ, Hewett L, Hall L, Li J, Ayub M – Adapted Dialectical Behaviour Therapy (DBT) group for Individuals with Intellectual Disabilities and Emotional Dysregulation Difficulties (9-2015/9-2017) Queen’s Department of Psychiatry 

Kennedy S, Jokic R – CANBIND/OBI Integrated Biological Markers for the Prediction of Treatment Response in Depression (1-2013 / N/A) CANBIND 

Kennedy S, Soares C – CAN-BIND Canadian Biomarker Integration Network in Depression (5-2012/5-2017) Ontario Brain Institute 

Kirkham J, Seitz D – Canadian Frailty Network Interdisciplinary Fellowship Award (1-2016/12-2016) Canadian Frailty Network 

Khalid-Khan S, Reddy S – A Multicentre, Double blind, Placebo and Active Controlled Parallel Group Evaluation of the Safety and Efficacy of Vilazodone in Pediatric Patients with Major Depressive Disorder (11-2016/12-2018) Allergan 

Khalid-Khan S, Reddy S –An Adaptive Phase II-B/III, Double-Blind, Randomized Placebo Controlled, Multi-Centre Study Of The Safety And Efficacy Of Naben ® (Sodium Benzoate), A D-Amino Acid Oxidase Inhibitor, as an Add-on Treatment Of Schizophrenia in Adolescents (10-2014/12-2018) SyneuRx International (Taiwan) Corporation 

Khalid-Khan S, Wilson C, McCart A, Jaffer A – Centralized triage for children and adolescents with mood and anxiety disorders (9-2015/9-2016) SELHIN 

Khalid-Khan S, McCart A, Wilson C – Decreasing Wait Times for Child and Youth Mental Health: Developing a Centralized Triage Process between Primary Care, Youth Mental Health Agency and Child and Adolescent Psychiatry in the Hospital: A Quality Improvement Initiative (4-2014/3-2017) SELHIN

Khalid-Khan S, Calancie O, Nesdole R – Expansion of the Centralized Triage for Children and Adolescent Neurodevelopmental Disorders (11-2015/N/A) RBC for Children’s Mental Health 

Khalid-Khan S, Khachatryan D – Prazosin Treatment of Nightmares and Sleep Disturbances Associated with PTSD in Children and Adolescents (9-2016/12-2018) Department of Psychiatry Grant

Khalid-Khan S, Booij L, Davidson J, McCart A – Preventing Aggressive Behaviour in Boys Exposed to Family Violence (11-2016/12-2019) Department of Psychiatry Internal Grant 

Khalid-Khan S, Reddy S, Roberts N – Sandbox/TELUS: Providing Patients Access to Personalized Health Care Through Accessible Youth and Provider Friendly Technology: Sandbox Project Phase 2 (10-2014/10-2017) Sandbox 

Khalid-Khan S, Reddy PS – Developing triage services in Kingston (4-2015/12-2018) SEAMO 

Kolar D, Milev R, Cabrera-Abreau C, Jokic R – The Validation of the Nepean Dysphoria Scale (6-2013/N/A) Research Initiated Grant 

Kolar D, Milev R, Cabrera C, Jokic R – A study of alertness in patients with treatment resistant depression (1-2015/12-2019) Queen’s RIG 

Liu X, Reddy P, Khalid-Khan S, Fitzpatrick R, Jones J – QPOND Genetic Studies of Autism, Neurodevelopmental and Neuropsychiatric Disorders (10-2015/10/2018) Ontario Brain Institute 

Liu X, Khalid-Khan S, Booij L – Genetics of Neuropsychiatric Disorders, including schizophrenia, mood disorders and eating disorders (11-2013/N/A) Special Grant 

Luctkar-Flude M, Groll D, Beckett L, Giroux J, Tyerman J – Exploring the effect of neurofeedback on post cancer cognitive impairment and fatigue: A pilot feasibility study (1-2016/1-2018) Canadian CAM Research Fund and Queen’s University School of Nursing 

Magaud E, Duffy A, Bentall R, Scott J – Clinical Risk Markers in the Early Stages of Bipolar Disorder (5-2015 / 5-2017) Alberta Innovates Health Solutions 

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – CANBIND-1 An Investigation of Biological Markers of Treatment Response in Depression (1-2013 / 12-2018) CANBIND and OBI 

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – Esketamine 3008 – Extension- An open label, long-term, extension safety study of intranasal Esketamine in treatment resistant depression (1-2016/12-2020) Janssen 

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – Esketamine 3001 – A randomized, double-blind, multi-centre, active-controlled study to evaluate the efficacy, safety and tolerability of fixed doses of intranasal Esketamine plus an oral antidepressant in adult subjects with treatment resistant depression (1-2016/12-2019) Janssen 

Milev R, Cabrera-Abreu C - A Randomized, Double-blind, Multicentre, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Subjects with Treatment-resistant Depression (9-2015/N/A) Janssen 

Milev R, Cabrera-Abreu C, Kolar D – An Investigation of Biological Markers of Treatment Response in Depression (4-2013 / N/A) UHN/OBI 

Milev R, Cabrera-Abreu C, Kolar D, Jokic R – Esketamine 3003-Extension – A randomized, double-blind, multicenter, active-controlled study of intranasal Esketamine plus an oral antidepressant for relapse prevention in treatment-resistant depression (1-2016 / 12-2018) Janssen 

Milev R, Cabrera-Abreu C, Kolar D – Extension – A Randomized, Double-blind, Multicenter, Active-controlled Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Treatment-Resistant Depression (12-2016 / N/A) Janssen 

Milev R, Cabrera-Abreu C, Kolar D – Extension – An Open-label long-term extension Safety Study of Intranasal Esketamine in Treatment-Resistant Depression (12-2016 / N/A) Janssen 

Milev R, Cabrera-Abreu C, Kolar D – Long-Term Follow Up Study Protocol – An Investigation of Biological Markers of Treatment Response in Depression (6-2016/N/A) UHN/OBI 

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – Mood Stabilizer Plus Antidepressant versus Mood Stabilizer Plus Placebo in the Maintenance Treatment of Bipolar Disorder (6-2013/12-2018) UBC

Milev R, Cabrera-Abreu C, Jokic R, Kolar D – Sleep architecture in depressed patients treated with Desvenlafaxine (1-2013/12-2017) Pfizer 

Milev R, Cabrera-Abreu C – Transcranial Magnetic Stimulation (rTMS) and Deep Brain Stimulation (DBS) across Ontario sites (existing and new) using the same standardized assessment platforms (2-2014 / N/A) External Agency 

Milev R, Cabrera-Abreu C, Kolar D – Wellness Monitoring – A Collaborative Investigation of Predictors of Relapse in Major Depressive Disorder – Extension – An Investigation of Biological Markers of Treatment Response in Depression (6-2016/N/A) UHN/OBI 

Milev R, Harkness K – Stress Sensitivity and Reward Responsivity in Major Depression: A 6-month Follow Up (6-2016/5-2017) FHS, Queen’s University and Kingston General Hospital Foundation Funds 

Milev R, Iftene F – A Multicentre, 26-Week Extension Study to Evaluate the Safety and Clinical Effects of Prolonged Exposure to 1 and 2mg doses of EVP-6124, an Alpha-7 Nicotinic Acetylcholine Receptor Agonist, as an Adjunctive (1-2013 – N/A) EnVivo Pharmaceuticals Inc. 

Milev R, Iftene F – A Phase II Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial to Examine the Efficacy and Safety of 4 Oral Doses of BI 425809 Once Daily over 12-week Treatment Period in Patients with Schizophrenia (1-2016 – N/A) Boehringer-Ingelheim 

Milev R, Iftene F – Canadian Non-Interventional Prospective Cohort Study on the Real Life (1-2013 / N/A) Abilify Maintenna 

Milev R, Iftene F – ENVIVO Study: A Randomized, Double-Blind, Placebo-Controlled, Parallel, 26-Week, Phase 3 Study of 2 Doses of Alpha-7 Nicotinic Acetylcholine Receptor Agonist (EPV-6124) or Placebo as an Adjunctive Pro-Cognitive Treatment in Schizophrenia Subjects on Chronic Stable Atypical Antipsychotic Therapy (1-2013 – N/A) EnVivo Pharmaceuticals Inc. 

Milev R, Iftene F, Millson R – Interventional, Randomized, Double-Blind, Active-Controlled, Fixed-Dose Study of LuAF35700 in Patients with Treatment-Resistant Schizophrenia (phase3) (1-2016 / N/A) Lundbeck 

Milev R, Iftene F – PANSS Development of a PANSS Subscale for the Clinical Staging of Schizophrenia:  Descriptive, Non-Interventional, Multi-Centre Study (1-2016/12-2017) Lundbeck 

Milev R, Iftene F – QUALIFY: A 28-week, Randomized, Open-Label Study Evaluating the Effectiveness of Aripiprazole Once-monthly Versus Paliperidone Palmitate in Adult Patients with Schizophrenia. Study Phase IIIb (1-2013 / N/A) Lundbeck 

Milev R, Jokic R – A Prospective, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Safety and Efficacy Study of Oral ELND005 as an Adjunctive Maintenance Treatment in Patients with Bipolar I Disorder (1-2013/12-2016) Elan Pharma International Inc. 

Milev R, Wallace C – The Efficacy, Safety and Tolerability of Probiotics on the Mood and Cognition of Depressed Patients (1-2016/12-2019) Lallemand and CANBIND 

Milev R, Munshi T, Marin A, Cabrera C, Jokic R, Kolar D, Liu Y – CANBIND, Biomarkers in Depression (12-2012/N/A) Lundbeck 

Milev R, Munshi T, Abdelmotaal E, Iftene F – Add on therapy for Cognitive Deficits in Schizophrenia (12-2012/N/A) Shire 

Millson R, Iftene F – Serum Vitamin C and D Levels in Clients with Schizophrenia: A Retrospective Analysis (1-2015 – N/A) Department of Psychiatry Internal Grant 

Morgan D, Kosteniuk J, Connell ME, Kirk A, Stewart N, Acan Osman B, Auer S, Bourassa C, Bracken J, Dal Bello-Haas V, Defontaines B, Farmer J, Holroyd-Leduc J, Innes A, Jacklin K, Malloy-Weir L, Miller W, Mou H, Osgood N, Osman M, Parrott E, Quail J, Rohatinsky N, Seitz D, Walker J – Design and evaluation of integrated primary health care practices for dementia in rural and remote settings (9-2016/8-2021) CIHR 

Munshi T, Parmar V, Dhaliwal S – Nicotine Dependence in mental health patients, is it being identified! (7-2013/N/A) Queen’s Department of Psychiatry 

Nadkarni P, Wang P, Reddy PS, Groll D – Awareness of driving guidelines: a transatlantic comparison (4-2016) Queen’s Department of Psychiatry Research Assistance Funds 

Nadkarni P, Bajaj N, Hassan T, Groll D, Nadkarni S – Determinants of aggression control measures: data from an acute psychiatry ward (3-2016) Queen’s Department of Psychiatry Research 

Naeem F – A pilot RCT to test the effectiveness of CBTp based guided self-help for schizophrenia (6-2015 / 11-2016) Department of Psychiatry

Naeem F, Munshi T, Khalid-Khan S – Cognitive Behaviour Therapy (CBT) based guided self-help for patients with psychosis (6-2015/N/A) Queen’s Department of Psychiatry 

Naeem F, Munshi T, Ayub M, Bowie C, Hirji A, McKenna C, Johal R, Groll D – Cognitive Behaviour Therapy (CBT) based Guided Self-Help in combination with Cognitive Remediation for patients with Psychosis (8-2015/N/A) Queen’s Department of Psychiatry 

Naeem F, Munshi T, Johal R, Hirji A, McKenna C – RCT of Resolve (Relaxation exercise, solving problems and cognitive errors): A waiting room intervention for crisis clients (7-2015/N/A) Queen’s Department of Psychiatry 

Prost E, Shamblaw A – Review of Patients Seeking Psychiatric Services at a Women’s Reproductive Clinic (1-2015 – 1-2017) Queen’s Department of Psychiatry 

Prost E, Shamblaw A – Women’s Reproductive Clinic – Relationship and Treatment Outcome (5-2016 – 6-2017) Queen’s Department of Psychiatry 

Reddy PS, Nesdole R – Prejudiced attitudes towards Aboriginals in healthcare: the psychometric properties of the old-fashioned and modern prejudiced attitudes towards Aboriginals scale (12-2015/12-2016) Queen’s Internal Grant 

Reddy PS, Khalid-Khan S – Second Generation Antipsychotic Use And Side Effect Profile In Children And Adolescents: A Five Year Retrospective Study (10-2015/10-2018) Queen’s Initiation Grant 

Reddy PS, Edgington A, Binbing – Tool development for assessing the risks associated with psych pharmaceutical agent use in children: a pilot study with Atomoxetine (10-2015/10-2018) Queen’s Grant 

Rochon PA, Bronskill SE, Austin PC, Bell CM, Farrell B, Gill SS, Gruneir A, Herrmann N, Jeffs LP, McCarthy L, Metge C, Seitz DP, Upshur R – Multi-Method Approach to Exploring Prescribing Cascades (9-2016/8-2017) 

Seitz D, Gill SS, Herrmann N, Lanctot K, Kirkham J, Le Clair K, Maxwell C, Quinn t, Rapoport R, Rochon PA, Takwoingi Y – A Systematic Review and Meta-Analysis of the Accuracy of Depression Rating Scales to Diagnose Depression in Older Adults with Alzheimer’s Disease and Other Dementias (3-2015 / 2-2016) CIHR 

Seitz D, Herrmann N, Lanctot K – Non-Stigmatizing Language in Dementia (10-2016 / 11-2017) CIHR 

Seitz D, Herrmann N, Lanctot K – Prevention and Treatment of Neuropsychiatric Symptoms of Dementia (4-2014 / 3-2019) CIHR 

Seitz D, Rochon P, Herrmann N, Lanctot K, Tierney M – Sex and Gender Differences in the Initiation and Discontinuation of Psychotropic Medications among Long-Term Care Residents with Dementia (12-2016 / 11-2018) CIHR 

Seitz D, Austin P, Hussain M, Gill SS, Eckenhoff R, Berger M, Reimer CR – Surgery, Anesthesia, and Risk of Developing Dementia (1-2015 / 12-2017) SEAMO AFP Innovation Fund 

Seitz D – Comparative Safety of Antipsychotic Medications in Older Adults with Psychotic Disorders (10-2016) CIHR 

Seitz D – Mental Health Disorders in Long-Term Care (3-2016) Physician Services Incorporated 

Seitz D – Prevalence and Correlates of Multiple Medications with QTc Effects (1-2016) Alzheimer Society of Canada Research Program 

Soares C – Assessing the Acceptability of a Mobile Application in Depression: A M-Health User-friendliness, Feasibility Pilot Study (12-2016 / 12-2017) Ontario Brain Institute 

Soares C, Kennedy S – CAN-BIND CARES: Prevention and Self-Management of Depression in the Digital Age (9-2016/9-2019) Ontario Research Fund (ORF) Research Excellence 

Soares C, Frey B, Steiner M, Minuzzi L – Midlife Women with Depression: the effects of rapid tryptophan or phenylalanine/tyrosine depletion on mood and thermoregulation in depressed subjects responsive to estrogen therapy (3-2012/3-2017) CIHR

Velkers C, Seitz D – Canadian Frailty Network Interdisciplinary Fellowship Award (1-2016/12-2016) Canadian Frailty Network 

Vincent J, Kennedy J, Ayub M – Identification of Proteomic Biomarkers for Bipolar Disorder (3-2016.N/A) University of Toronto Neuroscience Catalyst Fund 

Wang L, Kolar D – Can the Use of a Safety Checklist Lead to Improve Quality of Care in Electroconvulsive Therapy? (1-2016/N/A) Queen’s University

Warner J, O’Neil J, Luctkar-Flude M, Groll D – Hotel Dieu Hospital Kingston RNAO Best Practice Spotlight Organization Implementation Project (9-2012/9-2016) RNAO

Wijeratne T, Nadkarni P, Wijeratne N, Hussein M, Al-Blowi M – SSRI and Bone Health (7-2015 / 12‑2016) Kingston General Hospital